Titanium Toxicity

Titanium Toxicity

TITANIUM. Chemical element, Ti, atomic number 22 and atomic weight 47.90. Its chemical behaviour shows many similarities with that of silica and zirconium, as an element belonging to the first transition group. Its chemistry in aqueous solution, especially in the lower oxidation states, has some similarities with that of chrome and vanadium. Titanium is a transition metal light with a white-silvery-metallic colour.

Titanium Element
Titanium (Ti)

Titanium is a commonly used inert bio-implant material within the medical and dental fields. It is one of the most widely used materials for dental implants due to its mechanical strength and a long history of use. Current titanium is thought to be safe but in some cases, there are reports of problems caused by titanium. 

There is no known biological role for titanium. In most of these problematic reports, only individual reports are dominant and comprehensive reporting has not been performed. Cause of these implant failures can be poor oral hygiene, uncontrolled deposition of plaque, and calculus around the implant which cause peri-implantitis or occlusal problems. 

Titanium Products

Titanium is commonly used in industrial applications such as coatings for pharmaceuticals, processing materials for gum and confections, food additives, and paints. It is also used in manufacturing associated with packing, milling and is used in the cleaning industry so titanium ends up in your food and water supply. In the medical field, titanium and titanium alloys have been used to fabricate various implantation and fixation systems. Many metal products have titanium added to increase strength.

With the widespread use of titanium, there are concerns regarding the adverse effects of titanium accumulation and its effects on the human body. Therefore, stability and potential hazards of it should also be evaluated and discussed.

Raw Titanium
Raw Titanium

Can Titanium cause health problems and does it have any side effects?

Titanium is not considered a toxic metal but it is a heavy metal and it does have serious negative health effects. Titanium has the ability to affect lung function causing lung diseases such as pleural disease, it can cause chest pain with tightness, breathing difficulties, coughing, irritation of the skin or eyes.  It is carcinogenic and may also cause cancer.

Symptoms of titanium toxicity

Symptoms associated with titanium vary depending on the amount you are currently exposed to, here are some of the more common symptoms:

  • Lung diseases
  • Skin diseases (Eczema)
  • Sinus congestion
  • Cancer
  • Vision problems
  • Sexual weakness (Premature ejaculation)
  • Bright’s disease (a disease involving chronic inflammation of the kidneys)
  • Lupus (any of various diseases or conditions marked by inflammation of the skin)

Additional symptoms of titanium toxicity

Titanium has the ability to interact with the essential mineral silica, therefore signs and/or symptoms of silica deficiency can be an indication of a titanium excess.

It’s important to understand that vitamin & mineral supplementation can NOT resolve titanium toxicity and may cover up symptoms leading to bigger problems.  Detoxification of titanium is essential to properly restoring vitamin and mineral imbalances.

Silica deficiency –  soft or brittle nails, premature wrinkles, thinning or loss of hair, poor bone development and osteoporosis can all be indications of titanium toxicity.

titanium toxicity and genetics

Titanium toxicity & genetics

Some people are genetically predisposed to titanium toxicity. This is because certain genes belonging to liver detoxification pathways that normally deal with titanium detoxification have been deleted. In these cases, a genetics test can confirm and a specialized nutritional program can help the individual detoxify barium.

Upcoming Seminar  on Titanium Particles and Peri-Implantitis

MYTHS, FACTS AND TREATMENT IMPLICATIONS
PIKOS SYMPOSIUM 2020

Peri-implantitis has been receiving attention following recent studies that showed that it is highly prevalent and difficult to manage. This course will provide the latest evidence-based information on peri-implant diseases with emphasis on a team/interdisciplinary approach to treatment. The program will present the updates on the definition and etiology of peri-implantitis from the American Academy of Periodontology 2018 consensus meeting. The instructor will present research findings on risk factors for peri-implant disease and preventive measures to incorporate into the implant treatment plan prior to implant placement that include implant treatment planning, material selection for cementation, restorative design and maintenance. In addition, the program will review innovative therapeutic protocols for disease prevention and treatment and recent advancements in Implant cleaning instruments and chemotherapeutics.

Learning Objectives:

  1. Review the New 2018 classification of peri-implant diseases and conditions. 
  2. Assess Titanium implant corrosion as an etiologic factor for implant failure.
  3. Determine the implant of professional cleaning on titanium surface damage.
  4. Describe the steps of an efficacious implant-driven peri-implantitis therapy protocol.

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7 thoughts on “Titanium Toxicity

  1. Chris Thomas says:

    [Allergic potential of titanium implants]

    Schuh A, Thomas P, Kachler W, Göske J, Wagner L, Holzwarth U, Forst R.

    Abstract

    AIM:
    The aim of this investigation is to evaluate the allergic potential of titanium and titanium alloys for surgical implant applications.

    MATERIALS AND METHODS:
    Discs cut from rods supplied by five different titanium suppliers in several diameters were investigated. The samples were cp-Titanium as well as Ti6Al4 V and Ti6Al7Nb, 6 mm thick with a diameter of between 6 and 60 mm. The material was checked by optical spectral analysis.

    RESULTS:
    In all samples except iodidtitanium, a Nickel content of 0.012-0,034 wt% could be detected.

    CONCLUSION:
    The low nickel content in the implant material results from the production process. The nickel atoms are in solid solution in the titanium lattice. Nickel allergic patients may develop hypersensitivity reactions even due to this low nickel content. Hence, this reaction may be falsely attributed to the titanium material itself. Measurements of ion concentration in the body are helpful for quantifying the maximum content of nickel in titanium materials for surgical implant applications. In addition, technical questions related to the production of nickel free titanium materials for allergic patients have to be solved.

    PMID: 15706453

  2. Chris Thomas says:

    Oral factors affecting titanium elution and corrosion: an in vitro study using simulated body fluid.
    Suito H, Iwawaki Y, Goto T, Tomotake Y, Ichikawa T.

    Source
    Department of Oral and Maxillofacial Prosthodontics and Oral Implantology, Institute of Health Biosciences, The University of Tokushima, Tokushima, Japan.

    Abstract

    OBJECTIVES:
    Ti, which is biocompatible and resistant to corrosion, is widely used for dental implants, particularly in patients allergic to other materials. However, numerous studies have reported on Ti allergy and the in vitro corrosion of Ti. This study investigated the conditions that promote the elution of Ti ions from Ti implants.

    METHODS:
    Specimens of commercially pure Ti, pure nickel, a magnetic alloy, and a gold alloy were tested. Each specimen was immersed in a simulated body fluid (SBF) whose pH value was controlled (2.0, 3.0, 5.0, 7.4, and 9.0) using either hydrochloric or lactic acid. The parameters investigated were the following: duration of immersion, pH of the SBF, contact with a dissimilar metal, and mechanical stimulus. The amounts of Ti ions eluted were measured using a polarized Zeeman atomic absorption spectrophotometer.

    RESULTS:
    Eluted Ti ions were detected after 24 h (pH of 2.0 and 3.0) and after 48 h (pH of 9.0). However, even after 4 weeks, eluted Ti ions were not detected in SBF solutions with pH values of 5.0 and 7.4. Ti elution was affected by immersion time, pH, acid type, mechanical stimulus, and contact with a dissimilar metal. Elution of Ti ions in a Candida albicans culture medium was observed after 72 h.

    SIGNIFICANCE:
    Elution of Ti ions in the SBF was influenced by its pH and by crevice corrosion. The results of this study elucidate the conditions that lead to the elution of Ti ions in humans, which results in implant corrosion and Ti allergy.

    PMID: 23762461

  3. Barbara says:

    I have a titanium plate due to brain surgery. My plate site has been sore and itchy (externally). Can this be an allergic reaction?

  4. Barbara Kutscher-Eddins says:

    I suffer from titanium dioxide allergy amd have a 4 level fusion. I am having the worst time trying to get treatment. My symptoms are atypical of most Vasculitis and no one has done arterial and Venus diagnostic testing.

    I get seizures, uncontrolled HTN, skin eashes and itching all over, steady high weight regardless of ldecrease in size of my fat deposits, thickened skin systemically, fibrosis (chemo) veins, and constant pain. There are more affects i am experiencing.

    My body has literally been trying to extract the metal from my neck. So far 1 plate, confirmed by xray, has been broken. In my case my body is trying to rid itself of the metal so it breaks it down and then the metal ions attach to protein complexes in the body. That complex is what causes the allergic response.

    I k n ow something else snapped in my neck because my blood pressure bottomed out amd a coworker almost started CPR on me. Since then my symptoms are much worse. I cannot find an MD willing to treat me.

  5. Kathleen says:

    I would like to know this as well I had a meningioma brain tumor removed and then a titanium plate over my skull. What are the long term effects?

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