bio prf 1
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science behind bioprf
bio prf 1

The first commercially available horizontal centrifuge specifically designed for the production of Platelet Rich Fibrin

Studies Related To PRF:


PRF as a Barrier Membrane in Guided Bone Regeneration

After reading this article, the individual will learn, the clinical relevance of using platelet-rich fibrin (PRF) as a barrier membrane,
and the advantages and disadvantages of combining PRF over or under
a standard collagen barrier membrane for routine guided bone regeneration

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  • Anfossi G, Trovati M, Mularoni E, Massucco P, Calcamuggi G, Emanuelli G. 1989. Influence of propranolol on platelet aggregation and thromboxane b2 production from platelet-rich plasma and whole blood. Prostaglandins, leukotrienes, and essential fatty acids. 36(1):1-7.
  • Cai YZ, Zhang C, Lin XJ. 2015. Efficacy of platelet-rich plasma in arthroscopic repair of full-thickness rotator cuff tears: A meta-analysis. Journal of shoulder and elbow surgery / American Shoulder and Elbow Surgeons [et al]. 24(12):1852-1859.
  • Choukroun J, Ghanaati S. 2018. Reduction of relative centrifugation force within injectable platelet-rich-fibrin (prf) concentrates advances patients’ own inflammatory cells, platelets and growth factors: The first introduction to the low speed centrifugation concept. European journal of trauma and emergency surgery : official publication of the European Trauma Society. 44(1):87-95.
  • Chow TW, McIntire LV, Peterson DM. 1983. Importance of plasma fibronectin in determining pfp and prp clot mechanical properties. Thrombosis research. 29(2):243-248. Delaini F, Poggi A, Donati MB. 1982. Enhanced affinity for arachidonic acid in platelet-rich plasma from rats with adriamycin-induced nephrotic syndrome. Thrombosis and haemostasis. 48(3):260-262.
  • Dohan Ehrenfest DM, Del Corso M, Diss A, Mouhyi J, Charrier JB. 2010. Three-dimensional architecture and cell composition of a choukroun’s platelet-rich fibrin clot and membrane. Journal of periodontology. 81(4):546-555.
  • Ehrenfest DMD, Rasmusson L, Albrektsson TJTib. 2009. Classification of platelet concentrates: From pure platelet-rich plasma (p-prp) to leucocyte-and platelet-rich fibrin (l-prf). 27(3):158-167.
  • El Bagdadi K, Kubesch A, Yu X, Al-Maawi S, Orlowska A, Dias A, Booms P, Dohle E, Sader R, Kirkpatrick CJ et al. 2017. Reduction of relative centrifugal forces increases growth factor release within solid platelet-rich-fibrin (prf)-based matrices: A proof of concept of lscc (low speed centrifugation concept). European journal of trauma and emergency surgery : official publication of the European Trauma Society.
  •  Fijnheer R, Pietersz RN, de Korte D, Gouwerok CW, Dekker WJ, Reesink HW, Roos D. 1990. Platelet activation during preparation of platelet concentrates: A comparison of the platelet-rich plasma and the buffy coat methods. Transfusion. 30(7):634-638.
  • Fujioka-Kobayashi M, Miron RJ, Hernandez M, Kandalam U, Zhang Y, Choukroun J. 2017. Optimized platelet-rich fibrin with the low-speed concept: Growth factor release, bio compatibility, and cellular response. Journal of periodontology. 88(1):112-121.
  • Ghanaati S, Al-Maawi S, Herrera-Vizcaino C, Alves GG, Calasans-Maia MD, Sader R, Kirkpatrick CJ, Choukroun J, Bonig H, Mourao C. 2018. A proof of the low speed centrifugation concept in rodents: New perspectives for in vivo research. Tissue engineering Part C, Methods. 24(11):659-670.
  • Ghanaati S, Booms P, Orlowska A, Kubesch A, Lorenz J, Rutkowski J, Landes C, Sader R, Kirkpatrick C, Choukroun J. 2014. Advanced platelet-rich fibrin: A new concept for cell-based tissue engineering by means of inflammatory cells. The Journal of oral implantology. 40(6):679-689.
    Jameson C. 2007. Autologous platelet concentrate for the production of platelet gel. Lab Med. 38:39-42.
  • Kobayashi E, Fluckiger L, Fujioka-Kobayashi M, Sawada K, Sculean A, Schaller B, Miron RJ. 2016a. Comparative release of growth factors from prp, prf, and advanced-prf. Clinical oral investigations.
  • Kobayashi E, Fluckiger L, Fujioka-Kobayashi M, Sawada K, Sculean A, Schaller B, Miron RJ. 2016b. Comparative release of growth factors from prp, prf, and advanced-prf. Clinical oral investigations. 20(9):2353-2360.
  • Kubesch A, Barbeck M, Al-Maawi S, Orlowska A, Booms PF, Sader RA, Miron RJ, Kirkpatrick CJ, Choukroun J, Ghanaati S. 2018. A low-speed centrifugation concept leads to cell accumulation and vascularization of solid platelet-rich fibrin: An experimental study in vivo. Platelets.1-12.
  • Marx RE. 2004. Platelet-rich plasma: Evidence to support its use. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons. 62(4):489-496.
  • Marx RE, Carlson ER, Eichstaedt RM, Schimmele SR, Strauss JE, Georgeff KR. 1998. Platelet-rich plasma: Growth factor enhancement for bone grafts. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. 85(6):638-646.
  • Meheux CJ, McCulloch PC, Lintner DM, Varner KE, Harris JD. 2016. Efficacy of intra-articular platelet-rich plasma injections in knee osteoarthritis: A systematic review.
  • Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association. 32(3):495-505.
  • Miron RJ, Fujioka-Kobayashi M, Hernandez M, Kandalam U, Zhang Y, Ghanaati S, Choukroun J. 2017a. Injectable platelet rich fibrin (i-prf): Opportunities in regenerative dentistry? Clinical oral investigations.
  • Miron RJ, Zucchelli G, Pikos MA, Salama M, Lee S, Guillemette V, Fujioka-Kobayashi M, Bishara M, Zhang Y, Wang HL et al. 2017b. Use of platelet-rich fibrin in regenerative dentistry: A systematic review. Clinical oral investigations. 21(6):1913-1927.
  • Singh B, Goldberg LJ. 2016. Autologous platelet-rich plasma for the treatment of pattern hair loss. American journal of clinical dermatology.
  • Wang X, Zhang Y, Choukroun J, Ghanaati S, Miron RJ. 2017. Behavior of gingival fibroblasts on titanium implant surfaces in combination with either injectable-prf or prp. International journal of molecular sciences. 18(2).

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