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Patterns of COVID-19 Mortality and Vitamin D: An Indonesian Study
04
Jun
Jun
Authors: Prabowo Raharusun, Sadiah Priambada, Cahni Budiarti, Erdie Agung, Cipta Budi
Date Written: April 26, 2020
Disclaimer: This is a preliminary study for early dissemination of results. Data are subject to changes.
Patterns of COVID-19 Mortality and Vitamin D: An Indonesian Study
Key Findings:
- Majority of the COVID-19 cases with insufficient and deficient Vitamin D status died.
- The odds of death was higher in older and male cases with pre-existing condition and below normal Vitamin D levels.
- When controlling for age, sex, and comorbidity, Vitamin D status is strongly associated with COVID-19 mortality.
- Randomized controlled trials are warranted to investigate the role of vitamin D supplementation on COVID-19 outcomes and to establish the underlying mechanisms.
ABSTRACT
This is a retrospective cohort study which included two cohorts (active and expired) of 780 cases with laboratory-confirmed infection of SARS-CoV-2 in Indonesia. Age, sex, co-morbidity, Vitamin D status, and disease outcome (mortality) were extracted from electronic medical records.
The aim was to determine patterns of mortality and associated factors, with a special focus on Vitamin D status. Results revealed that majority of the death cases were male and older and had pre-existing condition and below normal Vitamin D serum level.
Univariate analysis revealed that older and male cases with pre-existing condition and below normal Vitamin D levels were associated with increasing odds of death. When controlling for age, sex, and comorbidity, Vitamin D status is strongly associated with COVID-19 mortality outcome of cases.
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do you have a reference for this report yet, even as a pre print?